IAB (U1209/UMR5309)
Site Santé - Allée des Alpes
38700 La Tronche
tel: +33 (0)4 76 54 95 82
fax: +33 (0)4 76 54 94 25


Since December 2015: Research Engineer (IR) at IAB, INSERM, Grenoble, France. Data analysis and modelling of biological systems.

September 2012 - November 2015: Post Doctoral position at LBMC, CNRS, Lyon, France. Dynamic simulation of a gene regulatory network in various wild genetic backgrounds of yeast. project SiGHT (ERC-StG2011-281359) (Systems Genetics of Heritable variaTions)

September 2009 - August 2012: Senior Engineer position at LIP, Inria, Lyon, France. Design and implementation of a peer-to-peer grid middleware supporting petascale architecture. SPADES project (08-ANR-SEGI-025) (Servicing Petascale Architectures and DistributEd System)

Janury 2008 - August 2009: Post Doctoral position at Irstea (ex-Cemagref), Clermont-Ferrand, France. Compared study, design and implementation of Individual Based Model (IBM) and Differential Equation Model (DEM). Application to predator-prey model that incorporates individual behavior of the predators. Sensitivity analysis of from model parameters, impact on model behavior. LifeGrid / PatRes project (FP6-043268) (Pattern Resilience)

October 2004 - December 2007: Ph.D. position at France Telecom / University of Caen Basse-Normandie, Caen, France. Conception design and implementation of an ubiquitous services platform integrating distributed multimodal interfaces. AURORA Project (ITEA-03005)


2018: Journée Campagnes de calculs reproductibles, 23 october, Lyon (69), France.

2017: Epigenetic & High-Dimension Mediation Data Challenge. 7-9 June, Aussois (73), France.

2017: Rencontres scientifiques des Grands Causses : Modélisation physique de l’organisation nucléaire et de ses pathologies. 9-12 Mai, Millau (12), France.

2016: Capture de conformation de chromosomes : vers l’analyse tridimensionnelle de la régulation des génomes. 2-4 Mai, Bordeaux (33), France.

2015: DU in statitics (3/3) at University of Strasbourg. 16-20 November, Strasbourg (67), France.

2015: “R pour le calcul”, R avancé et performances. 5-9 October, Aussois (73), France.

2015: DU in statitics (2/3) at University of Strasbourg. 15-19 June Strasbourg (67), France.

2015: Advanced Lecture Course on Computational Systems Biology. 6-11 April, Aussois (73), France.

2015: DU in statitics (1/3) at University of Strasbourg. 19-23 January, Strasbourg (67), France.

2012: Advances Lecture Course Hybrid Multicore Parallel Programming, 8-12 October, Autrans (38), France.

2012: Wellcome Trust Advanced Course: In Silico Systems Biology. 23-27 April, Cambridge, UK.

2009: Mexico Advanced Course in Sensitivity Analysis. 11-14 May, Hyères (83), France.


2016: DU degree in statitics at University of Strasbourg,Strasbourg, France.

2007: Ph.D. degree in computer science at University of Caen Basse-Normandie, Caen, France.

2004: DEA (master science) in computer science, artificial intelligence and algorithm at University of Caen Basse-Normandie, Caen, France.

2003: Maitrise (master’s degree) in applied Mathematics at University of Rouen, Rouen, France.

2002: Licence (under graduate) in Mathematics at University of Rouen, Rouen, France.

1999: DUT (two-year university degree in technology) in Chemistry at IUT (University Institute of Technology) of Rouen, Rouen, France.

1997: Baccalauréat (French secondary school diploma), science major, Rouen, France.

Research Publications

Nut Directs p300-Dependent, Genome-Wide H4 Hyperacetylation in Male Germ Cells. Shiota H, Barral S, Buchou T, Tan M, Couté Y, Charbonnier G, Reynoird N, Boussouar F, Gérard M, Zhu M, Bargier L, Puthier D, Chuffart F, Bourova-Flin E, Picaud S, Filippakopoulos P, Goudarzi A, Ibrahim Z, Panne D, Rousseaux S, Zhao Y, Khochbin S. Cell Rep. 2018 Sep 25;24(13):3477-3487.e6.

Pregnancy exposure to atmospheric pollution and meteorological conditions and placental DNA methylation. Emilie Abraham, Sophie Rousseaux, Lydiane Agier, Lise Giorgis-Allemand, Jörg Tost, Julien Galineau, Agnès Hulin, Valérie Siroux, Daniel Vaiman, Marie-Aline Charles, Barbara Heude, Anne Forhan, Joel Schwartz, Florent Chuffart, Ekaterina Bourova-Flin, Saadi Khochbin, Rémy Slama, Johanna Lepeule. Environment International. 2018. ISSN 0160-4120.

Assigning function to natural allelic variation via dynamic modeling of gene network induction. Richard M, Chuffart F, Duplus-Bottin H, Pouyet F, Spichty M, Fulcrand E, Entrevan M, Barthelaix A, Springer M, Jost D, Yvert G. Mol Syst Biol. 2018. Jan 15;14(1):e7803.

Exploiting single-cell quantitative data to map genetic variants having probabilistic effects. Chuffart F, Richard M, Jost D, Burny C, Duplus-Bottin H, Ohya Y and Yvert G. PLOS Genetics. 2016. Volume 12, Issue 8, pages 1-27.

The complex pattern of epigenomic variation between natural yeast strains at single-nucleosome resolution. Fabien Filleton, Florent Chuffart, Muniyandi Nagarajan, Helene Bottin-Duplus, Gael Yvert. Epigenetics & Chromatin. 2015. Jul 31;8:26.

MyLabStocks: a web-application to manage molecular biology materials. Florent Chuffart and Gael Yvert. Yeast. 2014. Volume 31, Issue 5, pages 179-184.

When Self-Stabilization Meets Real Platforms: an Experimental Study of a Peer-to-Peer Service Discovery System. Eddy Caron, Florent Chuffart, Cédric Tedeschi Future Generation Computer Systems. 2013. 29, 6 1533-1543.

SimExplorer : Programming Experimental Designs on Models and Managing Quality of Modelling Process. Florent Chuffart, Nicolas Dumoulin, Thierry Faure, and Guillaume Deffuant. International Journal of Agricultural and Environmental Information Systems. 2010. 1(1) :55-68.

Other Communications

Utilisation des ressources CIMENT dans le cadre du projet epimed: les besoins spécifiques de la bioinformatique pour l’analyse des données d’exome. Quentin Testard, Julien Thevenon, Jean-François Taly, Laure Raymond, Florent Chuffart. JCAD 2018, 24-26 october, Lyon (69), France.

Histone variants: critical determinants in tumour heterogeneity. Wang T, Chuffart F, Bourova-Flin E, Wang J, Mi J, Rousseaux S, Khochbin S. Front Med. 2018 Oct 2. doi: 10.1007/s11684-018-0667-3.

The role of bromodomain testis-specific factor, BRDT, in cancer: a biomarker and a possible therapeutic target. Ekaterina Flin, Florent Chuffart, Sophie Rousseaux, Saadi Khochbin. Cell J (Yakhteh) Volume 19, Supplement 1, Spring 2017

Heterogenety in Carcinogenesis Mechanism (the lung cancer example) Florent Chuffart. Kick-off PITCHER. Lyon, 9 mach 2017.

execo (APP creation deposit). Matthieu Imbert, Laurent Pouilloux, Florent Chuffart. APP. 2015.

A General Method to map Single-cell Probabilistic Trait Loci of the Genome. (Short Talk). Quatrièmes Rencontres R, 24-26 June 2015, Grenoble, France.

Functional Genetic Diversity of the Yeast Galactose Network. (Short Talk). CompSysBio, 6-11 April 2015, Aussois, France.

NucleoMiner 2.0: Detecting intra-species quantitative epigenomic variation at single-nucleosome resolution. (Poster). LyonSysBio, 19-21 November 2014, Villeurbanne, France.

Parallel Computing in R using the Bot Package. (Poster). Deuxièmes rencontres R. 27-28 Juin 2013, Lyon, France.

Optimization in a Self-stabilizing Service Discovery Framework for Large Scale Systems. (in Proceedings). Eddy Caron, Florent Chuffart, Anissa Lamani, Franck Petit SSS. 2012. 239-252.

Large scale P2P discovery middleware demonstration. (in Proceedings). Eddy Caron, Florent Chuffart, Haiwu He, Anissa Lamani, Philippe Le Brouster, Olivier Richard IEEE International Conference on Peer-to-Peer Computing (P2P), 1-2 September 2011, Kyoto, Japan. 152-153

Mise en oeuvre de la découverte de services pour des plateformes dynamiques à large échelle. (in Proceedings). Florent Chuffart, Haiwu He RenPar’20, 10-13 May 2011, Saint-Malo, France. RSTI, serie TSI, 31:8-9-10, 1101-1119.

Implementation and Evaluation of a P2P Service Discovery System: Application in a Dynamic Large Scale Computing Infrastructure. (in Proceedings). Caron, E.; Chuffart, F.; Haiwu He; Tedeschi, C. IEEE 11th International Conference on Computer and Information Technology (CIT). 2011. 41-46.

Declarative task delegation in OpenMOLE. (in Proceedings). R Reuillon, F Chuffart, M Leclaire, T Faure, N Dumoulin, D Hill. International Conference on High performance computing and simulation (HPCS). 2010. 55-62.

Applying a Moment Approximation to a bacterial biofilm individual-based model. (in Proceedings). J-D. Mathias, F. Chuffart, N. Mabrouk, and G. Deffuant. In ICCGI ’09 : Proceedings of the 2009 Fourth International Multi-Conference on Computing in the Global Information Technology, pages 138-143, Washington, DC, USA, 2009. IEEE Computer Society.

Record & replay: expérimentation d’un service multimodal. (in Proceedings). Antoine Bouyer, Florent Chuffart UbiMob ’09 Proceedings of the 5th French-Speaking Conference on Mobility and Ubiquity Computing. 2009. 19-23.

The Design of a Multimodal Platform: Experimentation of Record & Replay. (in Proceedings). Bouyer, A. ; Chuffart, F. ; Courval, L. Second International Conferences on Advances in Computer-Human Interactions. 2009. 1-6.

Design and Analysis of Computer Experiments with SimExplorer. (in Proceedings). Florent Chuffart, Thierry Faure, Nicolas Dumoulin, Romain Reuillon, and Guillaume Deffuant. European Simulation and Modelling Conference (ESM2008). 27-29 October 2008, Le Havre, France. 575-577.

Conception d’une plate-forme de services ubiquitaires intégrant des interfaces multimodales distribuées. (PhD thesis). Florent Chuffart. Université de Caen Basse-Normandie. 2007.

Construction d’une application vocale pour la sélection d’objets à l’aide d’un modèle basé sur les hypergraphes. (in Proceedings). Cyril Bazin, Florent Chuffart, and Jacques Madelaine. 9ème Conférence Internationale sur le Document Numérique. 18-20 Septembre 2006, Fribourg, Suisse. 43-58.

Aurora, multimodal messaging framework for ubiquitous web context. (Communication). F. Chuffart, F. Van Gool, and L. Courval. In W3C Ubiquitous Web Workshop. 2006.

Aurora, a framework enabling multimodal interactions. (in Proceedings). Florent Chuffart, Filip Van Gool, and Lionel Courval. In Workshop on International on Multimodal Multiparty Meeting Processing, ACM ICMI Workshop. 7 October 2005, Trento, Italy. 53-585.